It's not a citybuilder per say, and not ever coming, but Red Alert 3 mod, Paradox, which got cancelled unfortunately, had a Mediterranean Syndicate faction. It was a pure classic cyberpunk with all the Japanese influences replaced by Mediterranean/Ancient Greek and Roman. The gameplay was planned to be very citybuilder-like, for instance instead of base walls, you'd build "Company Housing", that is, large square structures that soak up a lot of damage, block vision and fire, and there were Vias, roads to boost vehicle movement speed. Oh, and there was plenty of shway stuff, like the most basic units, Auxilaries, were just hired street thugs, and there's monowire used by the infiltrator specialists and traps. Here's the article: http://paradox-modfanmadebackup.wikia.com/wiki/Mediterranean_Syndicate
On a side note, anyone here considered creating a game like that, or a mod, themselves?