I can't say, for sure, if Marisa is a loner. Yes, it's her personality to bother other people, but she still lives alone with nobody else. She still has a few things that she doesn't want anyone else to know. She wants to give people the impression that she's this bothersome and obnoxious jerk who invades people's private matters and does criminal things, when she is a hardworking and dedicated person, most likely having psychological issues that need resolving. After all, she didn't become that powerful by simply being a jerk, she had to work for it.
On the other hand, my case is that I don't hate or have strong feelings about other people, but I simply don't mind them. In fact, they're the ones who make existence really interesting and worth living, especially if you care about them some how. But I don't try to start conversations with them or try to make friends with them because I might be disturbing them or be simply bothering them. I don't want to bother other people, because I don't want to be bother either. I might sometimes have a little disdain for society or humanity sometimes when I see something being done wrong by them, but I also feel them same way when something or something does something wrong or idiotic. I'm not that cynical, intellectually egoistic or naively self-important to go full misanthropic all the time.
So, I guess, our relationship will be her trying to open up a topic and me replying to it. It's not as uncommon as it is for me, actually. In fact, this is the usual modus operandi for me in public when it comes to social interactions. So, I don't mind that.