One problem with the circuitry is the use of norepinephrine as a signal. Norepinephrine has multiple systemic actions aside from sexual function. It is the primary signal for stress (thus sex itself can be considered a stressful, though enjoyable activity). Norepinephrine also triggers energy on demand. It increases thermogenesis. It can lead to changes in thyroid function - up or down. It can lead to insulin resistance, increasing the need for insulin production. It can change renal function, leading to the loss of zinc, iodine and other minerals. It can activate immune system pro-inflammatory signaling. Etc.
If there are underlying problems which already increase stress or demand for norepinephrine signaling, then the sum of these and additional sexual activity can increase norepinephrine signaling excessively leading to the problems one can experience with sexual exhaustion. Some of the changes can lead to positive feedback signaling loops which are self-perpetuating - resulting in a prolonged illness, if triggered. Some of the positive feedback loops prolong sympathetic nervous system, i.e. norepinephrine, signaling. Some changes can result in nutrient deficiencies which cause prolonged dysfunction if not addressed.
In briefly reviewing the symptoms listed on the internet for over-masturbation or sexual exhaustion syndrome, I found the following:
anxiety depression insomnia lack of energy impaired memory mood swings loss of libido erectile dysfunction headaches body pain blurred vision flushed face constipation frequent urination dizziness palpitations hair loss
Note that these symptoms indicate a systemic problem. Generally, the systems involved include the nervous system, endocrine system, immune system, metabolism and nutrition.
Some simple associations between function and a few of the signals or nutrients that are most often affected are as follows:
Anxiety: norepinephrine, serotonin, cortisol, CRH, thyroid, dopamine, testosterone, progesterone, etc.
Depression: dopamine, inflammatory cytokines, iron, Vitamin A, B-vitamins, vitamin D, testosterone, etc.
Insomnia: norepinephrine, thyroid, cortisol, iron, etc.
Lack of energy: thyroid, inflammatory cytokines, norepinephrine, cortisol, insulin, iron, vitamin A, B-vitamins, salt-intake, etc.
Impaired memory: dopamine, norepinephrine, thyroid, inflammatory cytokines, B-vitamins, Vitamin A, etc.
Mood swings: norepinephrine, inflammatory cytokines, cortisol, testosterone, estradiol, thyroid, iron, Vitamin A, B-vitamins, protein intake, etc.
Loss of libido: norepinephrine, inflammatory cytokines, testosterone, estrogens, thyroid, cortisol, iron, zinc,
Erectile dysfunction: norepinephrine, inflammatory cytokines, testosterone, estrogens, thyroid, cortisol, nitric oxide, protein intake, etc.
Headaches: inflammatory cytokines, norepinephrine, cortisol, etc.
Body pain: inflammatory cytokines, norepinephrine, cortisol, thyroid, iron, aldosterone, etc.
Blurred vision: norepinephrine, thyroid, inflammatory cytokines, iron, etc.
Flushed face: norepinephrine, thyroid, inflammatory cytokines, iron, etc.
Constipation: thyroid, norepinephrine, etc.
Frequent urination: norepinephrine, thyroid, inflammatory cytokines, iron, etc.
Dizziness: norepinephrine, inflammatory cytokines, aldosterone, cortisol, nitric oxide, salt-intake, etc.
Palpitations: norepinephrine, inflammatory cytokines, cortisol, etc.
Hair loss: norepinephrine, thyroid, inflammatory cytokines, testosterone, estradiol, DHT, DHEA, zinc, biotin, etc.