Biologist working on CRISPR here.
>Crisper
If you can't even spell it, maybe you should find another hobby.
>How hard would DIY genetic manipulation be?
What exactly are you trying to manipulate? Introducing point mutations is pretty easy in flies or fish if you inject embryos. If you want mammals, good luck, even actual biologists hate making knockout mice without a very good reason (ie. Nature paper) because of how difficult it is.
For DIY, the big problems will be:
>figuring out how to sequence cheaply so you can confirm your manipulations
>obtaining dangerous chemicals like ems if doing mutagenesis
>budget is from $10k's to $1m's depending on scope
>ethics review for animal experiments
>storing samples without buying huge expensive -80C freezers and backup power system
>sterilizing shit without expensive autoclaves
Bacteria and other single cell organisms are doable, especially if you find a local hackspace or uni lab willing to accept volunteers.
>How hard is it to do IVF on mice?
Very hard. You can't do it on your own. Even with a PhD in relevant field it's hard. On your own, forget it.
>catgirls
Retarded idea, won't happen in your lifetime. Forget it.
If you are serious about this, change your major to Bio, get a Bio PhD from top 10 schools, learn Chinese and get a senior scientist job in China. You still won't be able to do it, but maybe a century after you're dead someone will do it based on the groundwork you laid down.
But who am I kidding, you can't even be bothered to Google the thing you want to work with to make sure you know how it's spelled. Good luck with your shit life.