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Catalog (/th/)

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Contribute

Please contribute banners, FAQ, and links to /th/ related boards and websites in this thread.

related boards:

>>>/cyber/

>>>/urbanate/

>>>/tech/

https://lainchan.org

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CEO of Bioviva alters herself to fight old age

Straight-up gene editing. World's first bioengineered transhuman?

https://www.reddit.com/r/Futurology/comments/3ocsbi/ama_my_name_is_liz_parrish_ceo_of_bioviva_the/

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Lifespan.io offers Unfucking Your Mitochondria (by duplicating information in your cells)

Mitochondria are vulnerable to mutation; cells are less vulnerable. 99% of the shit in your mitos is duplicated in your cells already, but the remaining 1% hasn't yet evolved in there.

These people aim to change that.

http://www.lifespan.io/campaigns/sens-mitochondrial-repair-project/

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College Decision

Hello /th/. I'm a high school senior and later in my life I want to do research that will significantly contribute to transhumanism. I need to make a decision by next month and I was just wondering where you guys think the best choice would be for me to being this path. I have been accepted to the following schools:
MIT
Columbia
Harvard
Princeton
UPenn
Dartmouth
Cornell
Georgia Tech
UCLA
UCSD
Johns Hopkins
Rice
Duke
Rutgers
Uillinois (urbana)
UMichigan
I'm currently leaning towards MIT but I thought I should get your input before I make a real decision.
Any opinions?
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What augments does /th/ want?

As for myself, I would very much like a mediport so that I would no longer have to deal with annoying injections and IV tubes and also so that I would be able to know my health information at all times as if I was playing a videogame that had a health hud. I would also love to have a flexible endoskeleton for having superagility and super kinetic damage redistribution.
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SENS talks reality

(Minor edits: comments directed to specific people have been knocked off.)

A cell needs to alter the methylation of the promoters for many genes in order to change the expression of many genes, so any change in the cell's internal or external environment to which the cell responds will lead to changes in its DNA methylation pattern; aging causes a massive amount of change in every cell, in its neighbors, and in the systemic environment (viz. parabiosis work, etc), so it's entirely to be expected that DNA methylation status will change sweepingly with age. Most obviously, when looking at blood cells: as "everybody knows," inflammation and oxidative stress in the blood rises with age for a variety of reasons (senescent cell accumulation, accumulation of cells homoplasmic for large mitochondrial DNA deletions, unresolved injury, age-related autoimmunity, rising burden of atherosclerotic lesions, etc, plus a variety of specific diseases of aging); oxidative stress both dysregulates expression of many genes, and elicits adaptive gene expression responses, while inflammation is itself mediated by gene expression (most clearly and consistently of interleukin-6). And we also know that levels of multiple hormones and other blood-borne signaling factors (TGF-β, GDF-11, etc) are also altered by aging damage; their signaling effects, too, are often mediated by changes in methylation of genes. At the same time, blood cells themselves are suffering damage that leads to changes in gene expression and accompanying methylation status, such as cellular senescence (driven by telomere attrition, oxidative stress, aberrant oncogene expression, etc) and involving in many cases demethylation of the p16 promoter) and the accumulation of anergic T-cells. (Contrariwise, there is now rather strong evidence that p16 hypermethylation can be detected in DNA in the blood of patients with some cancers (especially esophageal cancer): this is because tumor DNA escapes into the blood, and reflects the true mutations and epimutations that allow the cancer to escape senescence).

While some quick headline-generating results would be useful for fundraising, especially in the short term, the extension of lifespan of a model organism simply can't be achieved in the short term through the SENS "damage-repair" strategy. This is because multiple kinds of aging damage contribute to the degenerative aging process, and in order for the rejuvenation biotechnologies that SENS Research Foundation is working to develop to effect lifespan extension, we will require the development of a suite of rejuvenation biotechnologies: one each to remove, repair, replace, or render harmless one of the particular forms of aging damage whose accumulation plays an important role in setting a currently-normal lifespan. But the suite as a whole must be sufficiently comprehensive, or it will exert only a modest effect on lifespan. If you only rehabilitate foam cells in atherosclerotic lesions, or only reverse the age-related stiffening of major arteries, or only reverse thymic involution by developing engineered thymus tissue to restore naïve T-cell production, you will benefit the great majority aging people (or rodents) a little bit (and a very small number of people quite dramatically), but the average person (or mouse) won't actually live much longer, simply because of the "weakest link in the chain" problem. If heart attack doesn't get you, then it's cancer, or stroke, or Alzheimer's disease — or a hip fracture brought when your central vision is so blocked by the early stages ofmacular degeneration that you don't see the cat, trip across it, and then send your osteoporosis-weakened bones crashing to the floor.

Olshansky, for instance, has calculated that a complete and final cure for all ischemic heart disease would only gain an average person who has already made it to age 50 (and thus avoided death in childhood etc) ≤ 3.55 years of life.(1) Similarly, eradicating cancer nets ≤ 3.2 years; both together ("if one doesn't get you, the other will") ≤ 7.83 years; and both, plus ALL circulatory diseases and diabetes, 15.3 years (1). Dr. de Grey subsequently zeroed in on the key point in the specific context of development of rejuvenation biotechnologies:
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>tfw dead board

Anyone else continuing to not commit suicide solely because the Singularity is near?

Anyone else noticing that AI is infringing on human level abilities now (speech recognition, visual processing)?
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What measures can be taken to be a transhumanist right now? Diy tech and biohacking general I guess.

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New computer

Hello fellow bre/th/ren,i need help finding a pc i dont really care about the monitor i just need it to be under 1.2k or should i build my own pc?

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If you're under-30 and healthy now, and you ever die, it's because you fucked up.

Early-life cancer? You ingested or inhaled the wrong substances. You fucked up.

Late-life cancer? You failed to use your time productively to cure the cancer that eventually killed you or ensure that others would do so. It was very possible within the decades you had before it hit. You fucked up.

Car wreck? You should have seen it coming. You fucked up.

Killed intentionally by someone who hates you? You knew better than to piss him off. You fucked up.

Killed by stray bullets? You should have known better than to relax in that neighborhood or live there at all. You fucked up.

Diabetes? You should have known better than to eat that much sugary shit. You fucked up.

Atherosclerosis? You failed to use your life productively in removing this cause before it could kill you. It, too, was very possible within the decades you had before it hit. You fucked up.

Alzheimer's? You failed to ensure the development of science and perform daily habits that maintain your blood-brain barrier and prevent the accumulation of tau and amyloids. You fucked up.

We're at the point in nascent technological development that whatever kills you, it was your fault. Don't say there's nothing you can do about it. It doesn't matter what the cause is- if you're under the age of 30 and live in a Western country, and you die of literally anything from now until the end of the universe, it's because you failed to prevent your own death.
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Technocracy

Hello fellow Transhumanists.
I am the board owner of >>>/urbanate/ a board dedicated to the discussion of Technocracy.
Because Transhumanism is integral to all modern Technocratic models, I feel that cooperation between our boards is only natural.
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What is your favorite transhumanist book? Mine is The Transhumanist Wager.

http://en.wikipedia.org/wiki/The_Transhumanist_Wager

Protagonist Jethro Knights studies philosophy and sails around the world to promote indefinite life extension, desiring to live eternally through medicine, science, and technology. Love-interest and physician Zoe Bach, while sharing Knights' philosophical transhumanism, challenges him with her absolute belief in the afterlife, insisting that death is a part of life. Meanwhile, in America, transhumanists are being targeted and killed by Christian terrorists in cahoots with the popular anti-transhumanist Reverend Belinas.[7]

After his sailing trip, Knights suffers a devastating personal tragedy at the hands of Christian fundamentalists. At the same time, the United States Government becomes more theocratic and criminalizes transhumanist research, prompting Knights to build an independent floating city and sovereign state, Transhumania, so research can be continued. Governments around the world eventually grow afraid of the radical science being created on Transhumania, and they attack the seasteading city. Transhumania successfully defends itself, and Knights attempts to establish a transhuman-inspired civilization.[8][9]
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Redpill me on transhumanism

Here's a good video. Let's see others!
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Eclipse Phase Thread!

Corebook: http://robboyle.files.wordpress.com/2014/05/ps21000_eclipsephase_4thprinting.pdf

So, what is the best Eclipse Phase faction and why is it Scum?
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offical /th/ approved music thread

Hey anon-kuns, post /th/ approved music here.

I'll help get this thread going…
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Airoplanes are stupid!

Seriously… why the hell are we wasting vast ammounts of fuel and poluting the air sending human bodies around the world when signals are cheaper and easier to send…

Why not just use artifical bodies?!

Telepresense robots are comming into use and high speed internet makes them at least reasonably fast so you actually can have a fairly meaning full discusion with out all that muching about wasting fuel and dealing with jet lag…
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Thanks to Hotwheels for making this a Board of the Week

Since Hotwheels is obviously in need of serious, fundamental physical improvements that do not yet exist, it's no surprise that he got around to making this a BotW. (I just wish making it one attracted more posts.)

Of course, Hotwheels is in the minority; this is a somewhat esoteric topic, and it's not always clear how badly people need transhumanism/alteration unless they have a crippling medical condition or they've already received it- and sometimes not even then.

For example, take your average star of a Fat Person Story; such a person obviously needs to be improved, although that person seldom recognizes it (else it would not be a FPS) and the improvements need not be "transhuman" as such. A simple regime of calorie restriction and exercise will usually suffice.

To that end, I encourage all prospective transhumanists to take time to focus on their health; visceral fat, atherosclerosis, and diabetes WILL fucking kill you.
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What is /th/'s opinion on cryonics?

It seems to me like it should work - that even if your brain is scrambled quite a bit, everything is still there, so if you can figure out how the scrambling process works with nanometer accuracy (which requires supercomputers far beyond current capabilities, but there's no rule future supercomputers can't be the size of planets), and determine the location of molecules down to the angstrom (which we currently can't do for large objects which have to stay below 200K, but there's no physical law against it), you should be able to figure out what the brain looked like before it got scrambled, and recover the person.
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Man gets sick of not being able to walk, invents prosthetic legs

No neural connections, though.
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So /th/, why havn't you gotten a diy augment yet?
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http://kotaku.com/woman-puts-deus-ex-on-computer-chip-in-her-hand-1573033542
https://archive.today/FA4BC

how does it feel to know that the SJW cancer has already infested transhumanism?
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As I look at Captain Mecha and other mechanised people, I find that eternal life isn't always hapiness. It is because life is limited that people try hard to live, and to feel emotion for others, this is what creates kindness. That's what I have realised.

Mechanical bodies have got to be removed from the universe.

I've realised that living forever is no reason to obtain a mechanical body.
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Problem of Muslims

What are all the ISIS shitstains gonna do after the singularity? They obviously don't approve of augmenting/engineering the human body. They're ready to cripple communication networks or down a space elevator 9/11 style. The future cannot co-exist with these barbarians. But if we can't even solve the Middle East right now, what makes everybody so optimistic that advanced AIs/transhumans would fare any better against a bunch of kebabs with a nuke? Creation is stressful and arduous, destruction is instant and cathartic. In the hands of, say, ISIS, nanomachines and advanced AIs capable of engineering nukes, plagues, etc. could spell the death of humanity for the sake of their stupid fucking 6th-century caliphate.
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What tat should I get to represent our ideals?
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'Cyborg' is now a gender identity

Why do SJW's have to insert themselves into everything?

http://ieet.org/index.php/IEET/more/murphy20150128
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What if blacks turned themselves white?

Some professional blacks, sick of being associated with their ghetto cousins, alter themselves to become white.

What happens?
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>2015
>not being one with nature
>lel
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Reason goes immortalist

Economic right-wingers can be MUCH more easily convinced to embrace longevity tech than the left. None of that "it's unnatural" Gaian bullshit, and I haven't seen a single one talk seriously about holding it for a privileged few; that spectre comes entirely from the left.

http://reason.com/archives/2015/02/06/eternal-youth-for-all/
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What is Transhumanism?

What is Transhumanism?
Many people think Transhumanism is synonymous with cyberpunk; that its just living in a society where everyone has robot arms and legs, corporations are more powerful than the government, and there are neon lights everywhere. However this is not Transhumanism, this is cyberpunk. Cyberpunk is just a romanticized future of what the next step to the utopia of Transhumanism will be. And that is what Transhumanism is: a utopia or rather a philosophy of what the perfect utopia would be. I would say Transhumanism is a philosophy fundamentally based off of the teachings of Epicurus, in the way that all human action is based off of obtaining happiness and avoiding pain. Transhumanism is the answer to these desires. Transhumanism is the philosophy that a perfect utopia would consist of its people having two qualities: eternal bliss and eternal life, and the means to obtain the qualities is through technology.
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Damage Repair for People whose Hearts are Still Beating

Aubrey de Grey talks like he's gargling something, but he outlines a plan for biological immortality.
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Hello, fellow transhumanists. I'd like to invite you to join the Advancement Coalition Party over at >>>/sen/ - our party thread can be found here:

http://8ch.net/sen/res/10116.html

We need new members, as currently the party consists solely of myself and one other on-again, off-again member, and what better place to look for members than here, amongst likeminded people?

Active party members will be granted votes to participate. We currently have a pool of 47 votes to divide, so if you're interested, hurry on over.

Additionally, I will advertise this board from time to time, as I have good reasons to want to see it grow and flourish. I hope to see you there soon!
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Cheap wearable solution.


Ugly but functional raspberry pi Heads up display…

http://www.dx.com/p/2-8x-led-viewfinder-for-canon-eos-550d-161239#.VKaDW3vAjPM
http://www.dx.com/p/robopeak-2-8-usb-tft-display-module-for-raspberry-pi-cubieboard-pcduino-tv-sticks-router-284995#.VKaDXnvAjPM


audio input
http://www.dx.com/p/wolfson-pi-audio-card-for-raspberry-pi-green-312374#.VKaDjXvAjPM

and a raspberry pi of coarse
http://www.dx.com/p/raspberry-pi-project-board-mode-b-made-in-uk-green-334720#.VKaDp3vAjPM


There is already a raspberry pi inteligent assistant if you can put up with something python based… personally i want to use mono and speech recognition to code my own…

But i am a C# programmer so i want it running stuff i am familiar with..
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Deus Ex

Deus Ex thread. You didn't ask for this but you're getting it anyway.

Did anyone else find Darrow's explanation in the final act to be kinda stupid? Sarif might have been kind of a prick but at least he legitimately wanted to further humanity's progression into something more than human.
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How long until I can get a rotating vibrating detachable bioelectric robot dick?

Will the pussies of the future have birth control built in?