dcb961 No.268
Since Hotwheels is obviously in need of serious, fundamental physical improvements that do not yet exist, it's no surprise that he got around to making this a BotW. (I just wish making it one attracted more posts.)
Of course, Hotwheels is in the minority; this is a somewhat esoteric topic, and it's not always clear how badly people need transhumanism/alteration unless they have a crippling medical condition or they've already received it- and sometimes not even then.
For example, take your average star of a Fat Person Story; such a person obviously needs to be improved, although that person seldom recognizes it (else it would not be a FPS) and the improvements need not be "transhuman" as such. A simple regime of calorie restriction and exercise will usually suffice.
To that end, I encourage all prospective transhumanists to take time to focus on their health; visceral fat, atherosclerosis, and diabetes WILL fucking kill you.