http://www.pcgamer.com/fallout-4-patch-reportedly-breaks-mod-support/
>the patch also adds a new launcher that disables mods on startup, and the .INI edit that previously got around this limitation no longer works. There is a fix, but it's not the most streamlined process ever: You'll need to launch the Nexus Mod Manager, then launch Fallout 4, then switch back to the NMM and re-enable mods, then go back to Fallout 4
Ov fucking vey, looks like they don't want us using mods until the creation kit comes out.