I have things to add after looking around some more.
Apparently Honda's gender was not said explicitly in the manga, but from some lines by coworkers and his(?) general act most readers had assumed Honda to be a woman. From what I've seen most readers of Manga are surprised Honda got a male seiyuu.
Makes sense since it's based on a female Mangaka's real life experience even though most of the stories are exaggerated to hell, the characters being all non-human and mangaka hiding her identity is a way of keeping privacy for herself and the customers the stories are supposedly based on(Imagine if a doctor or psychiatrist became a mangaka and wrote stories about his patients doing dumb shit and called them based on a true story, it would be a no-no unless you hide their privacy well enough).
According to the director, producer side strongly asked Honda to be cast with a male seiyuu, even he was surprised at first(This is directors first work by the way).
When you think about it it makes perfect sense, why else would Honda fawn over the gaijin man and get asked to recommend BL by fujos immediately? It would definitely feel more in place and unique if Honda was cast a female seiyuu.
The reason for abruptly putting a skeleton on HRT might be because normally a female skeleton is so rare that I can't even think of an example right now, everyone would assume a skele is male from just looks. Or producer side's request comes from mangaka to protect her privacy further.
I first thought armor manager in charge of BL was authors self insert this episode before it said Honda is based on mangaka, I found it weird that her self insert was a man but turns out I was right on mark. Not only is the mangaka a woman but so was the MC originally.
I honestly have no idea why I even care this much about the background of this shit.